123639-61-2

Basic information

• Product Name: Fmoc-L-glutamic acid-gamma-benzyl ester
• Synonyms: N-ALPHA-FMOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-GLUTAMIC ACID GAMMA-BENZYL ESTER;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-GLUTAMIC-ACID-GAMMA-BENZYL ESTER;N-(9-fluorenylmethoxycarbonyl)-L-glutamic acid-gamma-benzyl ester;N-9-FLUORENYLMETHYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER;Fmoc-L-glutamic acid γ-benzyl ester;L-Glutamicacid,N-[(9H-fluoren-9-ylmethoxy)carbon;N-9-Fluorenylmethyloxycarbonyl-L-glutamicacidg-benzylester
• CAS NO: 123639-61-2
• Molecular Formula: C₂₇H₂₅NO₆
• Molecular Weight: 459.49
• Product Categories: Amino Acid Derivatives;Amino Acids;Glutamic acid [Glu, E];Fmoc-Amino Acids and Derivatives;Fmoc-Amino acid series
• Mol File: 123639-61-2.mol
• Article Data: 8

Chemical Properties

• Melting Point: Decomposes
• Boiling Point: 698.2 ºC at 760 mmHg
• Flash Point: 376.1 ºC
• Appearance: White powder
• Density: 1.289 g/cm³
• Vapor Pressure: 1.83E-20mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: 2-8°C
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: Fmoc-L-glutamic acid-gamma-benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-L-glutamic acid-gamma-benzyl ester(123639-61-2)
• EPA Substance Registry System: Fmoc-L-glutamic acid-gamma-benzyl ester(123639-61-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 123639-61-2(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

Fmoc-glu(obzl)-oh, is an amino acid derivative used in chemical synthesis and peptide chemistry.

InChI:InChI=1/C27H25NO6/c29-25(33-16-18-8-2-1-3-9-18)15-14-24(26(30)31)28-27(32)34-17-23-21-12-6-4-10-19(21)20-11-5-7-13-22(20)23/h1-13,23-24H,14-17H2,(H,28,32)(H,30,31)/t24-/m0/s1

Upstream product

• 57-88-5 cholesterol 

Downstream Products

• 1639394-80-1 NH₂-Met-Glu(Bzl)-(7-amino-4-carbamoylmethylcoumarin) 
• 1172596-40-5 benzyl (S)-4-(((9H-fluoren-9-yl)methoxy)carbonyl)amino-5-iodopentanoate 
• 1558029-85-8 C₂₃H₂₃N₃O₆ 

Relevant articles and documents

A novel and efficient method for cleavage of phenacylesters by magnesium reduction with acetic acid

(Equation Presented) In the present study, we use magnesium turnings as a new deprotection reagent for the phenacyl group during orthogonal organic synthesis in the presence of other esters and sensitive protecting groups. By applying the new magnesium turnings/acetic acid deprotection method, phenacyl group can be more easily combined with other protecting groups that are not compatible with the zinc/acetic acid method.

Phosphate linked oligomers

Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphorothioate, phosphodiester, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

Pyrrolidine-containing monomers and oligomers

The invention relates to pyrrolidine monomeric units and to oligomers which are joined via phosphate linkages, including phosphorothioate, phosphodiester and phosphoramidate linkages.