1236769-17-7Relevant academic research and scientific papers
Preparation and properties in vitro and in vivo of antitubercular pyrroles
Hearn, Michael J.,Chen, Michaeline F.,Terrot, Marianne S.,Webster, Eleanor R.,Cynamon, Michael H.
, p. 707 - 712 (2010)
(Chemical Equation Presented) 1-Acylamino-2,5-dimethylpyrroles were prepared in the exploration of heterocyclic structures useful for their antitubercular activity. The pyrroles were conveniently formed from the reaction of aromatic acid hydrazides with hexane-2,5-dione in water or ethanol, without resorting to acid catalysis. In each case, the procedure provided a single pyrrole in pure form, and the product was identified without difficulty on the basis of highly characteristic spectrometric features. Some members of this class have significant activities against drug-resistant tuberculosis in vitro and offer substantial protection in a rigorous mouse model of the disease.
