123685-24-5

Basic information

• Product Name: phloretin-2′-O-β-D-glucuronide
• Synonyms: phloretin-2′-O-β-D-glucuronide
• CAS NO: 123685-24-5
• Molecular Weight: 450.399
• Mol File: 123685-24-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: phloretin-2′-O-β-D-glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: phloretin-2′-O-β-D-glucuronide(123685-24-5)
• EPA Substance Registry System: phloretin-2′-O-β-D-glucuronide(123685-24-5)

Safety Data

• Hazardous Substances Data: 123685-24-5(Hazardous Substances Data)

Upstream product

• 60-82-2 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on 
• 2616-64-0 uridine diphosphoglucuronic acid 
• 2616-64-0 UDP-glucuronic acid 

Relevant articles and documents

Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases

Many O-glucuronides exhibiting various pharmacological activities have been found in nature and in drug metabolism. The glucuronidation of bioactive natural products or drugs to generate glucuronides with better activity and druggability is important in drug discovery and research. In this study, by using two uridine diphosphate (UDP)-dependent glucuronosyltransferases (GATs, UGT88D4 and UGT88D7) from plants, we developed two glucuronidation approaches, pure enzyme catalysis in vitro and recombinant whole-cell catalysis in vivo, to efficiently synthesize bioactive O-glucuronides by the glucuronidation of natural products. In total, 14 O-glucuronides with different structures, including flavonoids, anthraquinones, coumarins, and lignans, were obtained, 7 of which were new compounds. Furthermore, one of the biosynthesized O-glucuronides, kaempferol-7-O-β-d-glucuronide (3a), potently inhibited protein tyrosine phosphatase (PTP) 1B with an IC50 value of 8.02 × 10-6 M. Some of the biosynthesized O-glucuronides also exhibited significant antioxidant activities.