123685-47-2

Upstream product

• 461-82-5 4-(trifluoromethoxy)aniline 
• 82050-00-8 N-2-propynyl-4-(trifluoromethoxy)benzenamine 
• 58677-07-9 N-[6-(bromomethyl)-3,4-dihydro-4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide 

Downstream Products

• 123685-54-1 2-Amino-6-[[2-propynyl[4-(trifluoromethoxy)phenyl]amino]methyl]-4-(3H)-quinazolinone 

Relevant academic research and scientific papers

Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

The synthesis and biological activity of two series of nonclassical thymidylate synthase (TS) inhibitors are described. The first is a series of 10-propargyl-5.8-dideazafolic acid derivatives (10a-j) and the second is a series of the analogous 2-desamino

Substituted quinazolinones as anticancer agents

Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.