1236888-04-2

Basic information

• Product Name: ethyl 1-(p-methyl-benzyl)-7-oxo-1,4,5,6-tetrahydro-7H-indole-2-carboxylate
• Synonyms: ethyl 1-(p-methyl-benzyl)-7-oxo-1,4,5,6-tetrahydro-7H-indole-2-carboxylate
• CAS NO: 1236888-04-2
• Molecular Weight: 311.381
• Mol File: 1236888-04-2.mol

Chemical Properties

• CAS DataBase Reference: ethyl 1-(p-methyl-benzyl)-7-oxo-1,4,5,6-tetrahydro-7H-indole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-(p-methyl-benzyl)-7-oxo-1,4,5,6-tetrahydro-7H-indole-2-carboxylate(1236888-04-2)
• EPA Substance Registry System: ethyl 1-(p-methyl-benzyl)-7-oxo-1,4,5,6-tetrahydro-7H-indole-2-carboxylate(1236888-04-2)

Safety Data

• Hazardous Substances Data: 1236888-04-2(Hazardous Substances Data)

Upstream product

• 119647-73-3 ethyl 7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate 
• 104-82-5 4-Methylbenzyl chloride 

Downstream Products

• 1236887-93-6 ethyl 6-[(dimethylamino)methylidene]-1-(4-methylbenzyl)-7-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate 
• 1429642-26-1 C₂₀H₁₉ClN₂O₃ 
• 1429642-14-7 C₂₀H₂₀N₂O₃ 

Relevant articles and documents

PHOTOCHEMOTHERAPEUTIC HETEROCYCLIC AGENTS HAVING ANTIPROLIFERATIVE AND ANTINEOPLASTIC ACTIVITY

The present invention concerns the synthesis of new analogs of angelicins, pyrrolo [3,2-h]quinoline, for the treatment of pathologies having hyperproliferative character included those having neoplastic nature. The treatment is based on the combined actio

Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage

In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline - bioisosters of the angular furocoumarin angelicin - were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity against a panel of four human tumor cell lines and a great dose UV-A dependence, reaching IC50 values at submicromolar level. The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action.