Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide, also known as Argipressin, is a derived molecule composed of a sequence of specific proteinogenic amino acids (histidine, arginine, alanine, tryptophan, phenylalanine, and lysine). It is a hormone found in mammals, playing a significant role in water retention and blood pressure regulation. The hormone this peptide represents is arginine vasopressin (AVP), which is produced in the hypothalamus and secreted by the posterior pituitary gland. Deficiency or abnormality in this hormone can lead to medical conditions like diabetes insipidus or syndrome of inappropriate antidiuretic hormone secretion (SIADH). Its functionality and applications are often studied in neuroscience and endocrinology.
123689-72-5
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Basic information
- Product Name: histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide
- Synonyms: histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide;Melanostatin DM;L-Histidyl-D-arginyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
- CAS NO:123689-72-5
- Molecular Formula: C41H58N14O6
- Molecular Weight: 842.99
- EINECS: N/A
- Product Categories: N/A
- Mol File: 123689-72-5.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- Appearance: /
- Density: 1.44g/cm3
- Refractive Index: 1.688
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide(CAS DataBase Reference)
- NIST Chemistry Reference: histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide(123689-72-5)
- EPA Substance Registry System: histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide(123689-72-5)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 123689-72-5(Hazardous Substances Data)
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123689-72-5 Usage
Uses
Used in Medical Applications:Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide is used as a therapeutic agent for the treatment of conditions related to water retention and blood pressure regulation. It is particularly useful in managing diabetes insipidus, where it helps to reduce excessive urination and thirst by promoting water reabsorption in the kidneys.
Used in Research Applications:
Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide is used as a research tool in neuroscience and endocrinology to study the mechanisms of water balance, blood pressure regulation, and the role of arginine vasopressin (AVP) in the body. It aids in understanding the effects of AVP on various physiological processes and its potential implications in different medical conditions.
Used in Drug Development:
Histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide is used as a lead compound in the development of new drugs targeting the arginine vasopressin (AVP) system. By studying its interactions with receptors and other biological molecules, researchers can design more effective and targeted therapies for conditions related to water balance and blood pressure regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 123689-72-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,6,8 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.Calculate Digit Verification of CAS Registry Number 123689-72:
(8*1)+(7*2)+(6*3)+(5*6)+(4*8)+(3*9)+(2*7)+(1*2)=145
145 % 10 = 5
So 123689-72-5 is a valid CAS Registry Number.
InChI:InChI=1/C41H58N14O6/c1-24(51-38(59)32(15-9-17-48-41(45)46)53-37(58)29(43)20-27-22-47-23-50-27)36(57)54-34(19-26-21-49-30-13-6-5-12-28(26)30)40(61)55-33(18-25-10-3-2-4-11-25)39(60)52-31(35(44)56)14-7-8-16-42/h2-6,10-13,21-24,29,31-34,49H,7-9,14-20,42-43H2,1H3,(H2,44,56)(H,47,50)(H,51,59)(H,52,60)(H,53,58)(H,54,57)(H,55,61)(H4,45,46,48)/t24-,29-,31-,32+,33+,34-/m0/s1
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histidyl-arginyl-alanyl-tryptophyl-phenylalanyl-lysinamide
