1236921-61-1

Basic information

• Product Name: 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline
• Synonyms: 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline
• CAS NO: 1236921-61-1
• Molecular Weight: 295.187
• Mol File: 1236921-61-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline(1236921-61-1)
• EPA Substance Registry System: 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline(1236921-61-1)

Safety Data

• Hazardous Substances Data: 1236921-61-1(Hazardous Substances Data)

Upstream product

• 83012-13-9 2,8-bis-(trifluoromethyl)-4-chloro-quinoline 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 35853-41-9 2,8-bis(trifluoromethyl)quinolin-4-ol 

Downstream Products

• 1236921-69-9 (E)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(3-hydroxy-4-methoxybenzylidene)hydrazine 
• 1236921-67-7 (E)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(3-(1,1,2,2-tetrafluoroethoxy)benzylidene)hydrazine 
• 1236922-01-2 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(3-cyanophenyl)semicarbazide 
• 1236921-65-5 2-[(E)-{2-[2,8-bis(trifluoromethyl)quinolin-4-yl]hydrazinylidene}methyl]-5-fluorophenol 
• 1236921-70-2 (E)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(2-fluoro-4-methoxybenzylidene)hydrazine 
• 1236922-04-5 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(2-methoxyphenyl)semicarbazide 
• 1236922-07-8 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(2-fluorophenyl)thiosemicarbazide 
• 1236922-00-1 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(4-fluorophenyl)semicarbazide 
• 1236922-11-4 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(3-chlorophenyl)semicarbazide 
• 1236921-78-0 (E)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(3-(trifluoromethoxy)benzylidene)hydrazine 
• 1236922-05-6 1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-4-(3,5-dimethylphenyl)semicarbazide 
• 1236921-75-7 (E)-1-(2,8-bis(trifluoromethyl)quinolin-4-yl)-2-(cyclohexylmethylene)hydrazine 

Relevant articles and documents

Design, Synthesis, and Antifungal Evaluation of Novel Quinoline Derivatives Inspired from Natural Quinine Alkaloids

Inspired by quinine and its analogues, we designed, synthesized, and evaluated two series of quinoline small molecular compounds (a and 2a) and six series of quinoline derivatives (3a-f) for their antifungal activities. The results showed that compounds 3e and 3f series exhibited significant fungicidal activities. Significantly, compounds 3f-4 (EC50 = 0.41 μg/mL) and 3f-28 (EC50 = 0.55 μg/mL) displayed the superior in vitro fungicidal activity and the potent in vivo curative effect against Sclerotinia sclerotiorum. Preliminary mechanism studies showed that compounds 3f-4 and 3f-28 could cause changes in the cell membrane permeability, accumulation of reactive oxygen species, loss of mitochondrial membrane potential, and effective inhibition of germination and formation of S. sclerotiorum sclerotia. These results indicate that compounds 3f-4 and 3f-28 are novel potential fungicidal candidates against S. sclerotiorum derived from natural products.