1237-49-6

Basic information

• Product Name: p-Methylacetophenone 2,4-dinitrophenylhydrazone
• Synonyms: 1-(4-Methylphenyl)ethanone 2,4-dinitrophenyl hydrazone;4'-Methylacetophenone 2,4-dinitrophenylhydrazone;p-Methylacetophenone 2,4-dinitrophenyl hydrazone;p-Methylacetophenone 2,4-dinitrophenylhydrazone
• CAS NO: 1237-49-6
• Molecular Formula: C₁₅H₁₄N₄O₄
• Molecular Weight: 314.2961
• Mol File: 1237-49-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 463.7°Cat760mmHg
• Flash Point: 234.2°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 8.89E-09mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: p-Methylacetophenone 2,4-dinitrophenylhydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: p-Methylacetophenone 2,4-dinitrophenylhydrazone(1237-49-6)
• EPA Substance Registry System: p-Methylacetophenone 2,4-dinitrophenylhydrazone(1237-49-6)

Safety Data

• Hazardous Substances Data: 1237-49-6(Hazardous Substances Data)

Usage

General Description

p-Methylacetophenone 2,4-dinitrophenylhydrazone is a chemical compound that is formed by reacting p-methylacetophenone with 2,4-dinitrophenylhydrazine. It is commonly used in organic synthesis as a reagent for the identification and characterization of carbonyl compounds. p-Methylacetophenone 2,4-dinitrophenylhydrazone is often used in analytical chemistry to detect the presence of ketones and aldehydes in various samples. It forms yellow crystals and is sparingly soluble in water. Its main purpose is in the identification of carbonyl compounds through its characteristic melting point and spectral properties.

InChI:InChI=1/C15H14N4O4/c1-10-3-5-12(6-4-10)11(2)16-17-14-8-7-13(18(20)21)9-15(14)19(22)23/h3-9,17H,1-2H3

Upstream product

• 622-96-8 4-methylethylbenzene 
• 122-00-9 para-methylacetophenone 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 
• 76195-86-3 2,4-dinitrophenylhydrazine hydrochloride 
• 622-97-9 1-ethenyl-4-methylbenzene 

Downstream Products

• 122-00-9 para-methylacetophenone 

Relevant articles and documents

Synthesis of novel dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties as potential antibacterial agents

Three novel series of dihydrotriazine derivatives bearing 1,3-diaryl pyrazole moieties were designed, synthesized and evaluated in terms of their antibacterial and antifungal activities. Most of the synthesized compounds showed potent inhibition of several Gram-positive bacterial strains (including multidrug-resistant clinical isolates) and Gram-negative bacterial strains with minimum inhibitory concentration values in the range of 1–64 μg/mL. Compounds 4b and 4c presented the most potent inhibitory activity against Gram-positive bacteria (S. aureus 4220, MRSA 3167, QRSA 3519) and Gram-negative bacteria (E. coli 1924), with minimum inhibitory concentration values of 1 or 2 μg/mL. Compared with previous studies, these compounds exhibited a broad spectrum of inhibitory activity. The cytotoxic activity of the compounds 4a, 4b, 4c and 11n were assessed in L02 cells. In vitro enzyme study implied that compound 4c exerted its antibacterial activity through DHFR inhibition.

Synthesis and antimicrobial evaluation of (Z)-5-((3-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one derivatives

Background: An alarming increment in pathogenic resistance to existing anti-microbial agents is a serious problem and the treatment of these bacterial infections is becoming increasingly challenging. Therefore, there is an urgent need to develop novel ant

Efficient and highly aldehyde selective wacker oxidation

A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl2(MeCN)2, 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.