1237-75-8

Basic information

• Product Name: N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-2-naphthalenecarboxamide
• Synonyms: N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxynaphthalin-2-carboxamid;2-Naphthalenecarboxamide, N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-, 3-hydroxy;5-(3-Hydroxy-2-napht;Naphthol AS-BI (C.I. 37566);7-Bromo-3-hydroxy-N-(2-methoxyphenyl)-2-naphthamide;C.I.37566;C.I.Azoic Coupling Component 45;Naphtol AS-BI
• CAS NO: 1237-75-8
• Molecular Formula: C₁₈H₁₄BrNO₃
• Molecular Weight: 319.31
• EINECS: 248-048-3
• Product Categories: Miscellaneous Biochemicals;Intermediates of Dyes and Pigments
• Mol File: 1237-75-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 467.334 °C at 760 mmHg
• Flash Point: 236.435 °C
• Appearance: /
• Density: 1.544 g/cm³
• Vapor Pressure: 5.28E-07mmHg at 25°C
• Refractive Index: 1.764
• Storage Temp.: 2-8°C
• PKA: 8.42±0.40(Predicted)
• CAS DataBase Reference: N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-2-naphthalenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-2-naphthalenecarboxamide(1237-75-8)
• EPA Substance Registry System: N-(2,3-Dihydro-2-oxo-1H-benzimidazol-5-yl)-3-hydroxy-2-naphthalenecarboxamide(1237-75-8)

Safety Data

• Hazardous Substances Data: 1237-75-8(Hazardous Substances Data)

Usage

Preparation

O-Anisidine?and 7-Bromo-3-hydroxy-2-naphthoic acid?condensation

InChI:InChI=1/C18H13N3O3/c22-16-8-11-4-2-1-3-10(11)7-13(16)17(23)19-12-5-6-14-15(9-12)21-18(24)20-14/h1-9,22H,(H,19,23)(H2,20,21,24)

Upstream product

• 37-87-6 Naphtol AS-BI-β-D-glucoronide 
• 1779-11-9 7-bromo-3-hydroxy-2-naphthoic acid 
• 90-04-0 2-methoxy-phenylamine 

Downstream Products

• 77593-34-1 7-bromo-3-(2,3,4,6-tetra-O-acetyl-α-D-mannopyranosyloxy)-2-naphth-o-anisidide 
• 77583-93-8 7-bromo-3-(α-D-mannopyranosyloxy)-2-naphth-o-anisidide 
• 364372-01-0 methyl 2-{6-bromo-3-[N-(2-methoxyphenyl)carbamoyl]-2-naphthyloxy}acetate 

Relevant articles and documents

Partial Purification and Characterization of Two β-Glucoronidases from Alcaligenes NG-11

A strain of Alcaligenes isolated from soil was a good producer of β-glucuronidase, and the enzyme was purified from the cell-free extract by sequential column chromatography on DEAE-Toyopearl, Toyopearl HW-55F, and Phenyl-Sepharose CL-4B.By these procedures, two β-glucuronidases designated as β-glucuronidases I and II were purified 240- and 508-fold, respectively. β-Glucuronidase I, with a molecular weight of 75,000, had an optimum pH at 7.5 and the enzyme II, with a molecular weight of 300,000, and maximum activity at pH 6.0.Both enzymes were strongly inhibited by saccharo-1,4-lactone, glucaro-δ-lactam, p-chloromercuribenzoate, Hg2+, and N-bromosuccinimide. β-Glucuronidase I was active toward estrogen-3-β-glucuronides and inert toward β-glucuronide conjugates of menthol, estrogen-17β-, estrogen-16α-, androsterone-3α-, testosterone-17β-, cortisol-17α-. β-Glucuronidase II hydrolyzed all of these substrates. β-Glucuronidase I was inhhibited by phenolphthalein and its glucuronide.