123702-97-6

Usage

Uses

Used in Pharmaceutical Industry:
Moracin O is used as a therapeutic agent for its anti-diabetic properties, due to its inhibitory activity against enzymes involved in carbohydrate degradation, which can help in the management of diabetes.
Used in Neurodegenerative Disease Treatment:
Moracin O is used as a neuroprotective agent for its potential role in protecting nerve cells and reducing inflammation in the brain, making it a candidate for the treatment of neurodegenerative diseases.
Used in Cancer Therapy:
Moracin O is used as an anti-cancer agent, given its pharmacological activities that can contribute to the treatment and management of cancer.
Used in Cosmetics and Skin Care Industry:
Although not explicitly mentioned in the provided materials, due to its antioxidant properties, Moracin O could potentially be used as an ingredient in cosmetics and skin care products for its beneficial effects on skin health and protection against oxidative stress.

Upstream product

• 1155310-20-5 (R)-2-{6-[3,5-bis-(tert-butyl-dimethylsilanyloxy)-phenyl]-2,3,5,6-tetrahydrobenzo[1,2-b;5,4-b']difuran-2-yl}-propa-2-ol 

Related news

HIF-1α inhibitors: Synthesis and biological evaluation of novel Moracin O (cas 123702-97-6) and P analogues08/08/2019

The natural products moracins O and P exhibited potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tumour hypoxia. Systematic variations of the structures of benzofuran type moracins were made and structure-a...detailed

Relevant academic research and scientific papers

Bioactive benzofuran derivatives from cortex mori radicis, and their neuroprotective and analgesic activities mediated by mGluR1

Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3′-O-α-L-arabinopyranoside (1), (9R)-moracin P 9-O-β-D-glucopyranoside (2), (9R)-moracin P 3′-O-β-D-glucopyranoside (3), and (9R)-moracin O 10-O-β-D-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells. In addition, moracin O (5) and P (8) also demonstrated a remarkable inhibition of the acetic acid-induced pain. The molecular docking with metabotropic glutamate receptor 1 (mGluR1) results indicated that these neuroprotective benzofuran-type stilbenes might be the active analgesic components of the genus Morus, and acted by mediating the mGluR1 pathway.

The first total synthesis of moracin O and moracin P, and establishment of the absolute configuration of moracin O

The first total synthesis of the naturally occurring benzofurans, moracins O and P was achieved using a Sonogashira cross coupling reaction followed by in situ cyclization, and the absolute configuration of natural moracin O was established.