123715-95-7Relevant academic research and scientific papers
A simple and rapid automated radiosynthesis of [18F] fluoroacetate
Tang, Ganghua,Tang, Xiaolan,Wang, Mingfang,Li, Baoyuan,Liang, Mingquan,Wang, Quanshi
, p. 297 - 301 (2008)
Two fully automated synthetic procedures of [18F]fluoroacetate ([18F]FAC) have been developed using a modified commercial TRACERlab FXFN synthesizer. One was a two-step one-pot procedure, consisting of nucleophilic [18F]fluorination of benzyl-2-bromoacetate as a precursor with no-carrier-added [18F]fluoride, hydrolysis within the same [18F]fluorination reaction vessel, and purification with/without high-performance liquid chromatography (HPLC). The second procedure consisted of nucleophilic [18F]fluorination, hydrolysis on the column, and purification with SEP-PAK cartridges instead of HPLC. The radiochemical purity of [18F]FAC was >95% by the two procedures. The second procedure was a simple, rapid, and fully automated synthesis of [18F]FAC with a high and reproducible radiochemical yield exceeding 60% (decay uncorrected) within the total synthesis time less than 20 min. The new, simple, and rapid on-column hydrolysis procedure should be adaptable to the fully automated synthesis of [18F]FAC at a commercial fluoro-deoxyglucose synthesis module. Copyright
