123716-10-9Relevant academic research and scientific papers
Synthesis and hypolipidemic activity of diesters of arylnaphthalene lignan and their heteroaromatic analogs
Kuroda, Tooru,Kondo, Kazuhiko,Iwasaki, Tameo,Ohtani, Akio,Takashima, Kohki
, p. 678 - 684 (2007/10/03)
A series of diesters of arylnaphthalene lignan and their heteroaromatic analogs were synthesized and evaluated for hypolipidemic activity. The diesters with modifications at C-3 showed excellent hypocholesterolemic and high-density lipoprotein (HDL) cholesterol-elevating activities. Structure- activity analysis indicated that the 2-pyridylmethyl ester 51 has the optimum activity.
An Efficient Synthesis of Heterocyclic Analogs of 1-Arylnaphthalene Lignans
Kuroda, Tooru,Takahashi, Masami,Ogiku, Tsuyoshi,Ohmizu, Hiroshi,Nishitani, Takashi,et al.
, p. 7353 - 7357 (2007/10/02)
The heterocyclic analogs 5a-f, 16, and 20 of 1-arylnaphthalene lignans were synthesized by Diels-Alder reactions of acetoxy aldehydes 11a-f, 14, and 18 with dimethyl acetylenedicarboxylate.A pathway for formation of 5a-f, 16, and 20 through the intermediacy of heteroaromatic isobenzofurans derived from acetoxy aldehydes is discussed.
A New Method for Generation of 4- and 6-Aryl Thienofurans, and 3-Aryl Furopyridine
Kuroda, Tooru,Takahashi, Masami,Ogiku, Tsuyoshi,Ohmizu, Hiroshi,Kondo, Kazuhiko,Iwasaki, Tameo
, p. 1635 - 1636 (2007/10/02)
6-Aryl thienofurans 2a-c, 4-(3,4-dimethoxyphenyl)thienofuran 3a, and 3-(3,4-dimethoxyphenyl)furopyridine 4a, which were intercepted in situ by dimethyl acetylenedicarboxylate to give the corresponding Diels-Alder adducts in good yield
Phenyl benzothiophene hypolipidemic derivatives
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, (2008/06/13)
Biphenyl derivative of the formula: STR1 wherein R1 is hydrogen atom or a lower alkoxycarbonyl group and R2 is a lower alkoxycarbonyl group, or R1 and R2 are combined together to form a group of the formula: eac
