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General Description

1H-Indole-2-carboxaldehyde, 3-methyl-1-(2-propenyl)- is a chemical compound with the molecular formula C13H13NO. It is a derivative of indole and is commonly used in the synthesis of pharmaceuticals and agrochemicals. 1H-Indole-2-carboxaldehyde, 3-methyl-1-(2-propenyl)- is known for its aromatic and fruity odor, and it is often used as a flavoring or fragrance ingredient in various products. Additionally, it has been studied for its potential therapeutic properties, including its anti-inflammatory and antioxidant effects. Overall, this chemical serves multiple purposes in various industries and is an important building block for the synthesis of organic compounds.

Upstream product

• 83-34-1 3-Methylindole 

Relevant academic research and scientific papers

Stereoselective intramolecular hetero Diels-Alder reactions of 1-oxa-1,3-butadienes: Synthesis of novel annelated pyrrolo[1,2-a]indoles

Novel classes of pyrano-1,3-dioxane-, pyranopyrimidine- and pyranopyrazole-fused pyrrolo[1,2-a]indoles are synthesised via stereoselective intramolecular 1-oxa-1,3-butadiene hetero Diels-Alder reactions.

Microwave-assisted facile synthesis of [a]-annelated pyrazolopyrroloindoles via intramolecular azomethine imine 1,3-dipolar cycloaddition

The synthesis of [a]-annelated pyrazolopyrroloindoles via intramolecular 1,3-dipolar cycloaddition of in situ generated azomethine imine from N-allylated indole-2-carboxaldehyde, in regio- and stereoselective manner by using microwave irradiation is described. A one-pot strategy for the expedient synthesis of pyrazolopyrroloindoles has been developed.

RCM in indoles. A new entry to the mitosene skeleton

The RCM metathesis reaction catalyzed by Grubbs' ruthenium catalyst is used with a series of 1,2-disubstituted indoles leading with excellent yields to tricyclic compounds. When applied to 1-allyl-2-vinylindoles this methodology allows a new entry to the mitosene skeleton.

Nitrones and Oxaziridines. XLV. Formation of Pyrroloindoles by Intramolecular Nitrone Cycloaddition

The N-allylindole-2-carbaldehydes (5)-(8) and related methyl ketones (9)-(12) undergo reaction with N-methylhydroxylamine to give the cycloadducts (14)-(17) and (19)-(22), respectively.These adducts contain isoxazolidine rings fused to pyrroloindole systems.Corresponding cycloaddition of the N-propargylindole derivatives (24) and (25) could not be effected and the nitrone (26) was isolated.The adducts (14)-(17) underwent hydrogenolysis of the isoxazolidine N-O bond to give the amino alcohols (27)-(30), together with traces of the alcohols (31)-(34).X-Ray crystallographic data for the cycloadducts (15) and (16b) are presented.