1237493-54-7Relevant academic research and scientific papers
Microwave-assisted ruthenium-catalysed olefin metathesis in fluorinated aromatic hydrocarbons: A beneficial combination
Samojlowicz, Cezary,Borre, Etienne,Mauduit, Marc,Grela, Karol
experimental part, p. 1993 - 2002 (2011/10/13)
High conversions in ruthenium-based olefin metathesis of demanding substrates are commonly forced by using a high loading of a catalyst and conducting reactions at elevated temperature for extended times. However, in many cases this approach is not fully
Efficient ring-closing metathesis of alkenyl bromides: The importance of protecting the catalyst during the olefin approach
Gatti, Michele,Drinkel, Emma,Wu, Linglin,Pusterla, Ivano,Gaggia, Fiona,Dorta, Reto
supporting information; experimental part, p. 15179 - 15181 (2010/12/24)
We present the first productive ring-closing metathesis reaction that leads to the construction of cyclic alkenyl bromides. Efficient catalysis employing commercially available Grubbs II catalyst is possible through appropriate modification of the starting bromoalkene moiety.
A general enantioselective route to the chamigrene natural product family
White, David E.,Stewart, Ian C.,Seashore-Ludlow, Brinton A.,Grubbs, Robert H.,Stoltz, Brian M.
experimental part, p. 4668 - 4686 (2010/08/13)
Described in this report is an enantioselective route toward the chamigrene natural product family. The key disconnections in our synthetic approach include sequential enantioselective decarboxylative allylation and ring-closing olefin metathesis to form the all-carbon quaternary stereocenter and spirocyclic core present in all members of this class of compounds. The generality of this strategy is demonstrated by the first total syntheses of elatol and the proposed structure of laurencenone B, as well as the first enantioselective total syntheses of laurencenone C and α-chamigrene. A brief exploration of the substrate scope of the enantioselective decarboxylative allylation/ring-closing metathesis sequence with fully substituted vinyl chlorides is also presented.
