123751-65-5

Upstream product

• 123751-63-3 1-methoxy-4-(p-carbomethoxy)phenyl-1-pentene 
• 619-64-7 p-ethylbenzoic acid 
• 123751-61-1 4-((E)-4-Methoxy-1-methyl-but-3-enyl)-benzoic acid 
• 764-38-5 (3Z)-pent-3-en-1-ol 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 

Downstream Products

• 123751-71-3 1-(2'-amino-3'-cyano-5'-pyridyl)-2-(p-carbomethoxyphenyl)propane 
• 123751-72-4 4-amino-4-deoxy-10-methyl-5,10-dideazapteroic acid 
• 123751-74-6 10-methyl-5,10-dideazapteroic acid 
• 123751-69-9 1,1-dicyano-3-(piperidinomethylene)-5-(p-carbomethoxyphenyl)hex-1-ene 
• 123751-82-6 10-methyl-5,10-dideazaminopterin 
• 110716-44-4 10-methyl-5,6,7,8-tetrahydro-5,10-dideazafolic acid 
• 123751-76-8 2-{4-[2-(2-Amino-4-hydroxy-pyrido[2,3-d]pyrimidin-6-yl)-1-methyl-ethyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 123751-78-0 10-methyl-5,10-dideazaminopterin diethyl ester 
• 123751-80-4 2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-1-methyl-ethyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 123751-67-7 4-((E)-1-Methyl-4-piperidin-1-yl-but-3-enyl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective redox-relay oxidative heck arylations of acyclic alkenyl alcohols using boronic acids

A general, highly selective asymmetric redox-relay oxidative Heck reaction using achiral or racemic acyclic alkenols and boronic acid derivatives is reported. This reaction delivers remotely functionalized arylated carbonyl products from acyclic alkenol substrates, with excellent enantioselectivity under mild conditions, bearing a range of useful functionality. A preliminary mechanistic investigation suggests that the regioselectivity of the initial migratory insertion is highly dependent on the electronic nature of the boronic acid and more subtle electronic effects of the alkenyl alcohol.

Synthesis and Antifolate Properties of 10-Alkyl-5,10-dideaza Analogues of Methotrexate and Tetrahydrofolic Acid

Synthesis of the 10-methyl and 10-ethyl analogues of 5,10-dideazatetrahydrofolic acid (DDTHF), a potent inhibitor of glycinamide ribotide (GAR) formyltransferase, is reported.Key intermediates in the process were 10-methyl- and 10-ethyl-4-amino-4-deoxy-5,