1237512-75-2

Upstream product

• 211501-36-9 2-(2-hydroxy-1-methylethyl)-1H-isoindole-1,3(2H)-dione 
• 1237512-74-1 2-{2-[2,6-bis(bromomethyl)phenoxy]-1-methylethyl}-1H-isoindole-1,3(2H)-dione 
• 1237512-76-3 C₁₉H₁₆Br₃NO₃ 
• 85-44-9 phthalic anhydride 

Downstream Products

• 1237512-72-9 [2-(2-aminopropoxy)-1,3-phenylene]dimethanol 
• 1237512-85-4 [2-(2-aminopropoxy)-1,3-phenylene]dimethanol hydrochloride 

Relevant academic research and scientific papers

Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity

[2-(2-Aminopropoxy)-1,3-phenylene]dimethanol 1 and 4-(2-aminopropoxy)-3- (hydroxymethyl)-5-methylphenol 2, two dihydroxylated analogs of mexiletine - a well known class IB anti-arrhythmic drug - were synthesized and used as pharmacological tools to investigate the blockingactivity requirements of human skeletal muscle, voltage-gated sodium channel. The very low blocking activity shown by newly synthesized compounds corroborates the hypothesis that the presence of a phenolic group in the para-position to the aromatic moiety and/or benzylic hydroxyl groups on the aromatic moiety of local anesthetic-like drugs impairs either the transport to or the interaction with the binding site in the pore of Na+ channels.