1237533-33-3Relevant academic research and scientific papers
Synthesis of new N-sulfonyl monocyclic β-lactams and the investigation of their antibacterial activities
Jarrahpour, Aliasghar,Motamedifar, Mohammad,Zarei, Maaroof,Mimouni, Mostafa
, p. 287 - 297 (2010)
New monocyclic β-lactams 4-6 were synthesized by a ketene-imine [2+2] cycloaddition reaction. The prepared monocyclic -lactams 4-6 were cleaved by ceric ammonium nitrate (CAN) to give NH β- lactams 7-9. The NH -β- lactams were converted to N-sulfonyl -lactams 10-21 by treatment with four different sulfonyl chlorides in the presence of Et3N and 4-N,N-dimethylaminopyridine (DMAP). Some of these monocyclic β-lactams were active against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa.
Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors
Cai, Shaoyi,Zhu, Gengzheng,Cen, Xiaohong,Bi, Jingjie,Zhang, Jingru,Tang, Xiaoshan,Chen, Kun,Cheng, Kui
, p. 2041 - 2050 (2018/03/13)
Toll-like receptor 2 (TLR2) can recognize pathogen-associated molecular patterns to defense against invading organisms and has been represents an attractive therapeutic target. Until today, none TLR2 small molecule antagonist have been developed in clinic
