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1237535-76-0

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1237535-76-0 Usage

General Description

Tert-butyl 4-fluoropyridin-2-ylcarbamate is a chemical compound with the molecular formula C11H14FN3O2. It is a derivative of pyridine and contains a tert-butyl group, a 4-fluoro substituent, and a carbamate functional group. tert-butyl 4-fluoropyridin-2-ylcarbamate is commonly used in organic synthesis and medicinal chemistry as a building block for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activity, including its antitumor and antiviral properties. Overall, tert-butyl 4-fluoropyridin-2-ylcarbamate is a versatile chemical that has applications in both research and industry.

Check Digit Verification of cas no

The CAS Registry Mumber 1237535-76-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,3,7,5,3 and 5 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1237535-76:
(9*1)+(8*2)+(7*3)+(6*7)+(5*5)+(4*3)+(3*5)+(2*7)+(1*6)=160
160 % 10 = 0
So 1237535-76-0 is a valid CAS Registry Number.

1237535-76-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (4-fluoropyridin-2-yl)carbamate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1237535-76-0 SDS

1237535-76-0Relevant articles and documents

CHIRAL SYNTHESIS OF FUSED BICYCLIC RAF INHIBITORS

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Paragraph 0402; 0409-0410; 0437; 0451-0453, (2022/02/09)

The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitor enantiomers of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, with high enantiomeric excess (%ee). The disclosure also relates to method of using the compound of formula (I), (Ia), (Ib), (II), (IIa), or (IIb), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

FARNESOID X RECEPTOR AGONISTS AND USES THEREOF

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Paragraph 00454, (2020/04/25)

Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.

Method suitable for large-scale production of B-RAF kinase dimer inhibitor

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Paragraph 0053-0054, (2020/08/18)

The invention relates to a method for large-scale production of a B-RAF kinase dimer inhibitor 1-((1S, 1aS, 6bS)-5-((7-oxo-5, 6, 7, 8-tetrahydro-1, 8-diazanaphthalene-4-yl) oxy)-1a, 6b-dihydro-1H-cyclopropyl [b] benzofuran-1-yl)-3-(2, 4, 5- trifluorophenyl) urea (hereinafter sometimes referred to as a compound 1). The method enables impurities or by-products to be controlled to 0.05% or less without the use of expensive column chromatography operations. Thus, the method greatly reduces cost and is suitable for large-scale production.

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