1237538-95-2Relevant academic research and scientific papers
Direct access to upper rim substituted mono- and diaryloxy calix[4]arenes via bis(spirodienone) route
Thulasi, Sreeja,Babu, Jisha,Babukuttannair, Adarsh,Sreemathi, Viji,Varma, Ramavarma Luxmi
experimental part, p. 5270 - 5276 (2010/08/20)
A seemingly ipso-like nucleophilic substitution of the upper rim of p-tert-butylcalix[4]arene is accomplished by an indirect method involving calixF4larene derived bis(spirodienone). This method not only provides both mono and 1,3-diaryloxy calixarenes but also enables the synthesis of upper rim monothio substituted calix[4]arenes. A modification of the methodology can be successfully extended for the selective synthesis of mono- and 1,3-diquinone calyx[4]arenes having free hydroxyl groups at the lower rim, in fewer steps.
