1237588-79-2Relevant academic research and scientific papers
Synthesis, Modification, and Antimicrobial Activity of the N-Methylpiperazinyl Amides of Triterpenic Acids
Kazakova,Giniyatullina,Tolstikov,Medvedeva,Utkina,Kartashova
, p. 383 - 389 (2010)
N-methylpyperazinyl amides of betulinic, platanic, glycyrrhetic, oleanolic, ursolic, and moronic acids were synthesized and modified. Betulin and betulonic acid showed antimicrobial activity against Staphylococcus aureus at a concentration of 90 mg/ml, and betulin manifested a bacteriostatic effect against Klebsiella pneumoniae at a concentration of 60 mg/ml. Among the studied N-methylpyperazinyl amides, the highest activity against S. aureus was observed for a betulonic acid derivative. Pleiades Publishing, Ltd., 2010.
