123760-96-3Relevant articles and documents
Utilization of Fukuyama's sulfonamide protecting group for the synthesis of N-substituted α-amino acids and derivatives
Lin, Xiaodong,Dorr, Hilary,Nuss, John M.
, p. 3309 - 3313 (2000)
A novel and general route for the solid phase synthesis of N-substituted α-amino acids has been developed. This synthesis employs Fukuyama's 2- nitrobenzenesulfonamide protecting group for preparation of secondary amines. The versatility of this methodology is demonstrated by the facile synthesis of a trisubstituted diketopiperazine (DKP) skeleton. (C) 2000 Elsevier Science Ltd.