123775-53-1Relevant academic research and scientific papers
Synthesis of Polyfunctionally Substituted Pyridazines
Ghozlan, Said Ahmed Soliman,Mohamed, Mona Hassan,Fakhr, Yehia,Elnagdi, Mohamed Hilmy
, p. 293 - 296 (2007/10/02)
The pyridazines 3,4,5, and 7 were obtained by reaction of the hydrazone derivatives 2 with several reagents.By treatment of 5 with acetic acid/hydrochloric acid, the pyrazolopyridazine 6 was formed.The pyrido-pyridazine derivatives 8 and 9 were obtained by reaction of 2 and 3 with malononitrile and ethyl cyanoacetate, respectively, and the isoxazolo-pyridazines 11 by reaction of 3a,b with hydroxylamine hydrochloride in ethanolic sodium ethoxide solution.The intermediate 9 was separated by reaction of 3a,b with hydroxylamine hydrochloride in ethanolic sodium acetate solution.
