1237754-09-4Relevant academic research and scientific papers
Synthesis and evaluation of novel chromone analogs for their inhibitory activity against interleukin-5
Thanigaimalai, Pillaiyar,Le Hoang, Tuan Anh,Lee, Ki-Cheul,Sharma, Vinay K.,Bang, Seong-Cheol,Yun, Jun Ho,Roh, Eunmiri,Kim, Youngsoo,Jung, Sang-Hun
body text, p. 2531 - 2536 (2010/07/08)
A novel series of chromone analogs were synthesized and evaluated for their inhibitory activity against interleukin-5. Among them compounds 5-Cyclohexylmethoxy-3-(4-hydroxybenzyl)-4H-chromen-4-one (6a, 98% inhibition at 30?μM, IC50?50?=?7.6?μM) showed most potent activity. The structural requirement of chromone analogs possessing the inhibitory activity against IL-5 could be summarized as: (i) importance of hydrophobic group such as cyclohexylmethoxy at 5th position of ring A, (ii) requirement of ring B with small size of hydrogen bonding group with electron donating property such as phenolic hydroxyl group at 4th position and (iii) planarity of the chromen-4-one ring.
