1237764-75-8Relevant academic research and scientific papers
An efficient synthesis of 6,9-disubstituted purin-8-ones via copper-catalyzed coupling/cyclization
Zhong, Qi-Fei,Sun, Li-Ping
, p. 5107 - 5111 (2010)
An efficient and novel synthesis of 6,9-disubstituted purin-8-ones has been developed. Starting from dichloropyrimidin-5-ylcarbamate, CuCl/amino acid catalyzed coupling/cyclization reaction with amines was achieved to afford 9-substituted 6-chloropurin-8-ones. Then a microwave-assisted amination procedure was carried out for the synthesis of 6,9-disubstituted purin-8-ones in moderate to good yields.
