1237789-94-4Relevant academic research and scientific papers
Efficient iron-catalyzed Tsuji-trost coupling reaction of aromatic allylic amides through a sp3-carbon-nitrogen breaking
Jiang, Zhen-Yu,Zhang, Cai-Hua,Gu, Feng-Lei,Yang, Ke-Fang,Lai, Guo-Qiao,Xu, Li-Wen,Xia, Chun-Gu
supporting information; experimental part, p. 1251 - 1254 (2010/08/05)
The catalytic activation of sp3-carbon-nitrogen of allylic amides is generally difficult because of the inefficient leaving-group ability of the amide group. In this article, we have discovered for the first time that FeCl3-catalyzed Tsuji-Trost coupling reaction of aromatic allylic amides with active methylene compounds, cyclohexanone, and allytrimethylsilane work efficiently under mild conditions. Georg Thieme Verlag Stuttgart.
