1237802-15-1Relevant academic research and scientific papers
Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure-activity relationship studies
Sasikumar,Qiang, Li,Burnett, Duane A.,Cole, David,Xu, Ruo,Li, Hongmei,Greenlee, William J.,Clader, John,Zhang, Lili,Hyde, Lynn
scheme or table, p. 3632 - 3635 (2010/09/06)
Tricyclic sulfones were designed as γ-secretase inhibitors and found to have excellent potency. Extensive SAR shows that a large number of sulfonamides at position 7 of the tricycle are very well tolerated. Compounds such as 15a and 15c showed remarkable in vivo potency.
