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Relevant academic research and scientific papers

Transition Metal Ions and Amides. VIII. Discrimination between Different Models for the Complexation of Cu2+ with N,N'-Diglycyl-1,2-ethanediamine, N,N'-Diglycyl-1,3-propanediamine and Glycine Ethylamide by Potentiometric or by Spectrophotometri

The complexation of Cu2+ with 1,8-diamino-3,6-diaza-2,7-octanedione (=N,N'-diglycyl-1,2-ethanediamine, DED) and with 1,9-diamino-3,7-diaza-2,8-nonanedione (=N,N'-diglycyl-1,3-propanediamine, DPD) has been studied by potentiometric and by spectr

Direct joining of a heterogeneous pair of supramolecular nanotubes and reaction control of a guest compound by transportation in the nanochannels

Four novel amino-acid lipids were synthesized and then self-assembled in water to produce four different types of supramolecular nanotubes. The nanotubes consisted of a single monolayer of amino-acid lipids packed in parallel and had similar inner diameters and membrane wall thicknesses but dissimilarly charged surfaces. Mixing of nanotubes that had cationic exterior surfaces with nanotubes that had anionic exterior surfaces resulted in aggregation of the nanotubes. In contrast, mixing of nanotubes with cationic interior surfaces and nanotubes with anionic interior surfaces resulted in end-to-end joining of the two types of nanotubes via electrostatic attractions at the open ends to form heterogeneous nanotubes. Time-lapse fluorescence microscopy confirmed that a fluorophore could be transported through the heterogeneous nanotubes, which had alternating acidic and basic nanochannel segments. In addition, acidbase reactions of the fluorophore could be precisely controlled during transport. This nanotube-joining technique should be useful not only for the construction of multifunctional hybrid nanotubes but also for the production of nanoreactors for chemical/biological reactions and nano-devices for analysis and separation.

HIV INTEGRASE INHIBITORS

Hydroxy-substituted pyrazinopyrrolopyridazine dione compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dione compounds are of Formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.