123792-68-7

Basic information

• Product Name: 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE
• Synonyms: 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE;5,6,7,8-Tetrahydro-3-nitro-1,6-naphthyridine
• CAS NO: 123792-68-7
• Molecular Formula: C8H9N3O2
• Molecular Weight: 179.18
• Mol File: 123792-68-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 116-117 °C(Solv: hexane (110-54-3); toluene (108-88-3))
• Boiling Point: 325.5±42.0 °C(Predicted)
• Appearance: /
• Density: 1.304±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.82±0.20(Predicted)
• CAS DataBase Reference: 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE(123792-68-7)
• EPA Substance Registry System: 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE(123792-68-7)

Safety Data

• Hazardous Substances Data: 123792-68-7(Hazardous Substances Data)

Usage

Description

3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE is a chemical compound with the molecular formula C11H11N3O2. It is a nitro-substituted naphthyridine derivative that features a tetrahydro-naphthyridine structure with a nitro group attached to the 3-position. 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE is recognized for its potential biological activities and is utilized as a building block in the development of new drugs for treating various diseases. Its chemical structure and properties render it a valuable tool in drug discovery and development, particularly within the fields of pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the creation of new drugs that target a range of diseases, making it an essential part of drug discovery and development processes.
Used in Agrochemical Industry:
In the agrochemical sector, 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE serves as an intermediate in the synthesis of compounds with pesticidal properties. Its incorporation into these products can contribute to the development of effective and novel agrochemicals designed to protect crops and enhance agricultural productivity.
Given the compound's potential biological activities and applications in both the pharmaceutical and agrochemical industries, ongoing research and development efforts are likely to explore and expand its uses, further establishing 3-NITRO-5,6,7,8-TETRAHYDRO-[1,6]NAPHTHYRIDINE as a significant player in the chemical and life sciences.

Upstream product

• 355818-98-3 tert-butyl 3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate 
• 123792-65-4 6-acetyl-5,6,7,8-tetrahydro-3-nitro-1,6-naphthyridine 
• 104916-29-2 1-Acetyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine 

Downstream Products

• 948306-78-3 C₈H₁₁N₃ 
• 53454-30-1 3-Amino-1.6-naphthyridin 
• 13221-70-0 3-Nitro-1,6-naphthyridin 

Relevant articles and documents

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.

INVERSE ELECTRON DEMAND DIELS-ALDER REACTIONS OF 5-NITROPYRIMIDINE WITH ENAMINES. SYNTHESIS OF 3-NITROPYRIDINE DERIVATIVES

The reaction of cyclic and non-cyclic enamines with 5-nitropyrimidine has been studied.Many enamines react in an inverse electron-demand Diels-Alder reaction, leading to the formation of 3-nitropyridines.N,S-ketene acetals were also found to react with 5-nitropyrimidines.The mechanism of the reaction will be discussed.