123802-69-7

Upstream product

• 131451-99-5 triacetate of ACMP 
• 131451-93-9 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(R)-(2-benzyloxy-1-methanesulfonyloxy)ethyl>oxazolidin-2-one 
• 131451-94-0 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(R)-(2-hydroxy-1-methanesulfonyloxy)ethyl>oxazolidin-2-one 
• 131451-96-2 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-(1-hydroxy-2-morpholin-4-yl)ethyl>oxazolidin-2-one 
• 130914-07-7 (4S,5R)-3-Benzyl-5-<(R)-(2-benzyloxy-1-hydroxy)ethyl>-4-cyclohexylmethyloxazolidin-2-one 
• 131451-95-1 (4S,5R)-3-Benzyl-4-cyclohexylmethyl-5-<(S)-oxiran-2-yl>oxazolidin-2-one 
• 139056-96-5 (4R,5R)-4-<(S)-(1-(N-Benzyl-N-methoxycarbonyl)amino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 139056-97-6 (2R,3R,4S)-4-(N-Benzyl-N-methoxycarbonyl)amino-1-benzyloxy-5-cyclohexylpentane-2,3-diol 
• 130914-06-6 (4R,5R)-4-<(S)-(1-N-Benzylamino-2-cyclohexyl)ethyl>-5-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 164073-34-1 (2S,3S,4R)-1-morpholino-2,3-dihydroxy-4-azide-5-cyclohexylpentane 
• 164073-33-0 (2S,3S,4R)-1,2-epoxy-3-hydroxy-4-azide-5-cyclohexylpentane 
• 164073-32-9 (3S,4S)-3-hydroxy-4-azide-5-cyclohexyl-1-pentene 
• 164073-31-8 (3S,4R)-3-trimethylsilyloxy-4-hydroxy-5-cyclohexyl-1-pentene 

Downstream Products

• 133378-94-6 (2S,3R,4S)-4-N-tert-Butoxycarbonylamino-5-cyclohexyl-1-morpholin-4-yl-2,3-pentanediol 
• 131451-99-5 triacetate of ACMP 

Relevant academic research and scientific papers

A facile synthesis of (2S,3R,4S)-4-amino-5-cyclohexyl-1-morpholino-2,3-pentanediol, the C-terminal compound of renin inhibitor BW-175

A facile synthesis of (2S, 3R, 4S)-4-amino-5-cyclohexyl-1-morpholino-2, pentanediol (ACMP), the C-terminal compounds of renin inhibitor BW-175 is described.

N-ACYLAMINO ACID DERIVATIVES AND THEIR PHARMACEUTICAL COMPOSITIONS

An N-acylamino acid derivative of the formula: STR1 wherein the substituents are herein defined or a salt thereof, which is useful as hypotensive drugs.

Novel synthesis of three types of C-terminal components of renin inhibitors from unnatural (2S,3S)-tartaric acid

The addition reaction of cyclohexylmethylmagnesium bromide with the imine prepared from unnatural (2S,3S)-tartaric acid was found to proceed in a highly stereoselective manner in the presence of cerium(III) chloride. A chelation-controlled mechanism could

Novel Synthesis of (2S,3R,4S)-4-Amino-5-cyclohexyl-1-morpholino-2,3-pentanediol and (2S,3R,4S)-2-Amino-1-cyclohexyl-6-methyl-3,4-heptandiol, the C-Terminal Components of Renin Inhibitors

The title synthesis could be accomplished in a highly stereo-and regioselective manner by employing epoxide formation with inversion of configuration followed by epoxide opening with a nucleophile.