123811-74-5

Basic information

• Product Name: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE
• Synonyms: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;4-METHOXYPICOLINIC ACID HYDROCHLORIDE
• CAS NO: 123811-74-5
• Molecular Formula: C₇H₇NO₃*ClH
• Molecular Weight: 189.6
• Mol File: 123811-74-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 148-150 °C
• Boiling Point: 354.5°Cat760mmHg
• Flash Point: 168.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.22E-05mmHg at 25°C
• CAS DataBase Reference: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE(123811-74-5)
• EPA Substance Registry System: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE(123811-74-5)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 123811-74-5(Hazardous Substances Data)

Usage

General Description

4-Methoxy-pyridine-2-carboxylic acid hydrochloride is a chemical compound with the molecular formula C7H7NO3Cl. It is a derivative of pyridine and carboxylic acid, and it is commonly used in the synthesis of pharmaceuticals and agrochemicals. 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE is a white to off-white crystalline solid that is soluble in water and has a melting point of around 220-222°C. It is often used as a reagent in organic synthesis and as an intermediate in the production of various drugs. Additionally, it has potential applications in the development of new materials and compounds for research and industrial purposes.

InChI:InChI=1/C7H7NO3.ClH/c1-11-5-2-3-8-6(4-5)7(9)10;/h2-4H,1H3,(H,9,10);1H

Upstream product

• 1122-96-9 4-methoxypyridine N-oxide 
• 620-08-6 4-methoxypyridine 
• 36057-44-0 2-cyano-4-methoxylpyridine 

Downstream Products

• 135607-86-2 (2R,4S)-4-Methoxy-piperidine-2-carboxylic acid 
• 4043-87-2 pipecolic Acid 

Relevant articles and documents

Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics

Lack of new antibiotics and increasing antimicrobial resistance are among the main concerns of healthcare communities nowadays, and these concerns necessitate the search for novel antibacterial agents. Recently, we discovered the cystobactamids—a novel natural class of antibiotics with broad-spectrum antibacterial activity. In this work, we describe 1) a concise total synthesis of cystobactamid 507, 2) the identification of the bioactive conformation using noncovalently bonded rigid analogues, and 3) the first structure–activity relationship (SAR) study for cystobactamid 507 leading to new analogues with high metabolic stability, superior topoisomerase IIA inhibition, antibacterial activity and, importantly, stability toward the resistant factor AlbD. Deeper insight into the mode of action revealed that the cystobactamids employ DNA minor-groove binding as part of the drug–target interaction without showing significant intercalation. By designing a new analogue of cystobactamid 919-2, we finally demonstrated that these findings could be further exploited to obtain more potent hexapeptides against Gram-negative bacteria.

METHODS AND COMPOUNDS FOR INHIBITING MRP1

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