123811-87-0 Usage
General Description
1-Boc-1,2,3,4-tetrahydro-quinoline-2-carboxylic acid is a chemical compound used in organic synthesis and medicinal chemistry. It is a derivative of 1,2,3,4-tetrahydroquinoline, which has been identified as a potential bioactive scaffold in drug discovery. The compound contains a Boc (tert-butoxycarbonyl) protecting group, which can be removed under mild conditions to reveal the free amine group for further reactions. 1-Boc-1,2,3,4-tetrahydro-quinoline-2-carboxylic acid has been studied for its potential as a building block in the synthesis of biologically active molecules and pharmaceuticals, and it has shown promise in the development of new chemical entities with therapeutic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 123811-87-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,8,1 and 1 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 123811-87:
(8*1)+(7*2)+(6*3)+(5*8)+(4*1)+(3*1)+(2*8)+(1*7)=110
110 % 10 = 0
So 123811-87-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H19NO4/c1-15(2,3)20-14(19)16-11-7-5-4-6-10(11)8-9-12(16)13(17)18/h4-7,12H,8-9H2,1-3H3,(H,17,18)
123811-87-0Relevant articles and documents
THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
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Page/Page column, (2015/03/31)
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
An Improved Synthesis of Homoproline and Derivatives
Shuman, Robert T.,Ornstein, Paul L.,Paschal, Jonathan W.,Gesellchen, Paul D.
, p. 738 - 741 (2007/10/02)
An improved, general synthesis of substituted homoprolines has been developed by using readily available substituted pyridines (1).A key step in this synthetic procedure involves the known conversion of pyridine-N-oxides to 2-cyanopyridines (3) in nearly quantitative yields.The resulting nitriles are hydrolyzed to the corresponding pyridine-2-carboxylic acids (4).Subsequent reduction of the aromatic ring with PtO2/H2 gives the homoprolines (5) in good yields as racemic cis isomers.This procedure also can be utilized for the preparation of 5,6-benzohomoprolines fromthe appropriate quinoline precursors.The N-tert-butyloxycarbonyl (Boc) derivatives of these amino acids (useful intermediates for peptide synthesis) were also prepared in good yields.
