1238182-64-3Relevant academic research and scientific papers
Synthesis of 1,7-dioxaspiro[5.5]undecanes and 1 -oxa-7-thiaspiro[5.5] undecanes from exo-glycal
Lin, Hui-Chang,Chen, Yen-Bo,Lil, Zi-Ping,Wong, Fung Fuh,Lin, Chun-Hung,Lin, Shao-Kai
, p. 5229 - 5234 (2010)
A new spirocyclization was developed for the synthesis of 1,7-dioxaspiro[55]undecanes and 1-oxa-7-thiaspiro[55]undecanes by reaction of exo-glycal with awl alcohols or thiophenols in the presence of Lewis acid BF3·OEt2. The reaction proceeded through tandem Ferrier rearrangement, glycosylation, and FriedelCrafts alkylation to provide the corresponding products in good to excellent yields.
