123820-55-3

Basic information

• Product Name: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 1-(2-methoxy-phenyl)-ethyl ester
• CAS NO: 123820-55-3
• Molecular Weight: 368.353
• Mol File: 123820-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 1-(2-methoxy-phenyl)-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 1-(2-methoxy-phenyl)-ethyl ester(123820-55-3)
• EPA Substance Registry System: (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid 1-(2-methoxy-phenyl)-ethyl ester(123820-55-3)

Safety Data

• Hazardous Substances Data: 123820-55-3(Hazardous Substances Data)

Upstream product

• 13513-82-1 1-(2-methoxyphenyl)ethanol 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 13513-82-1 (1S)-1-(2-methoxyphenyl)ethan-1-ol 
• 135-02-4 ortho-anisaldehyde 

Relevant articles and documents

Stereoselective Synthesis of Homochiral Alpha Substituted o-Methoxybenzyl Alcohols via Nucleophilic Additions to Kinetically Resolved Homochiral Tricarbonyl(η6-o-anisaldehyde)chromium(0)

Tricarbonyl(η6-o-anisaldehyde)chromium(0) has been kinetically resolved via the selective hydrolysis of one of the L-valinol derived imine diasteroisomers in the presence of deactivated alumina.An X-ray crystal structure analysis on the adduct formed between L-valinol and homochiral (+)-tricarbonyl(η6-o-anisaldehyde)chromium(0) unambiguously established the presence of the corresponding imine and not oxazolidine and confirmed the absolute configuration of the aldehyde complex.Addition of Grignard reagents to homochiral tricarbonyl(η6-o-anisaldehyde)chromium(0) occurs completely stereoselectively to give, following decomplexation, homochiral alpha substituted o-methoxybenzyl alcohols.