1238210-10-0

Basic information

• Product Name: EMtricitabine Carboxylic Acid
• Synonyms: EMtricitabine Carboxylic Acid;Emtricitabine Carboxylic acid impurity;(2R,5S)-Emtricitabine Carboxylic Acid
• CAS NO: 1238210-10-0
• Molecular Formula: C8H8FN3O4S
• Molecular Weight: 261.2302232
• Product Categories: Heterocycles, Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 1238210-10-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Sparingly), Methanol (Slightly, Heated, Sonicated)
• CAS DataBase Reference: EMtricitabine Carboxylic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: EMtricitabine Carboxylic Acid(1238210-10-0)
• EPA Substance Registry System: EMtricitabine Carboxylic Acid(1238210-10-0)

Safety Data

• Hazardous Substances Data: 1238210-10-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Light Beige Solid

Uses

Emtricitabine Carboxylic Acid is an impurity of the antiviral agent Emtricitabine (E525035).

Upstream product

• 108-48-5 2,6-dimethylpyridine 
• 2022-85-7 Flucytosine 

Relevant articles and documents

Stereoselective synthesis of nucleoside analogues using bicyclic intermediate

The present invention relates to a process for producing predominantly pure cis nucleoside analogues of formula (I), wherein X is S, or O; Y is S, CH2, O or CH(R); wherein R is azido or halogen; and R2 is a purine or pyrimidine base; via the coupling of a silylated purine or pyrimidine base in the presence of an appropriate Lewis acid with a bicyclic intermediate of formula (III) wherein Z is S or O; followed by conversion of the resulting intermediate of formula (II) to an alkyl ester and reduction to yield a compound of formula (I). STR1