123834-59-3

Usage

Chemical structure

A benzene ring with two hydroxyl groups and a pyrazole ring attached to one of the benzene carbon atoms.

Functional groups

Hydroxyl (-OH) and pyrazole (C3H3N2)

Appearance

It may exist as a solid or crystalline substance, depending on the conditions.

Solubility

Generally soluble in organic solvents like ethanol, methanol, and dimethyl sulfoxide (DMSO), but may have limited solubility in water.

Stability

Stable under normal temperature and pressure, but sensitive to heat, light, and moisture.

Reactivity

Can undergo various chemical reactions, such as oxidation, reduction, and substitution, due to the presence of the hydroxyl and pyrazole groups.

Organic synthesis

Used as a building block for the creation of various biologically active compounds.

Pharmaceutical research

Potentially used in the development of drugs for a variety of diseases and conditions.

Agrochemicals

May have uses in the formulation of agrochemicals.

Specialty chemicals

Can be used as an intermediate in the production of specialty chemicals.

Biological activity

Due to its ability to interact with biological systems and modulate specific biochemical pathways, it has potential applications in drug development.

Safety precautions

Handle with care, as it may have potential hazards depending on its concentration and exposure. Use appropriate personal protective equipment (PPE) and follow proper storage and disposal guidelines.

Upstream product

• 288-13-1 NH-pyrazole 
• 123-31-9 hydroquinone 
• 106-51-4 p-benzoquinone 

Downstream Products

• 138152-19-9 2-(1H-pyrazol-1-yl)cyclohexa-2,5-diene-1,4-dione 

Relevant academic research and scientific papers

Oxidant-Induced Azolation of Electron-Rich Phenol Derivatives

Since N-arylazoles are widely present in natural products, pharmaceuticals, and functional materials, it is important to develop a simple and efficient synthetic method for the synthesis of N-arylazoles. Herein, an oxidant-induced intermolecular azolation of phenol derivatives was demonstrated under catalyst-free condition. Both monoazolation and diazolation of phenols can be successfully achieved via this practical and powerful method.

Reaction of Pyrazole Adddition to Quinones

The reactions of pyrazole, 4-nitropyrazole, 3,5-dimethylpyrazole, and 4-chloro-3,5-dimethylpyrazole with 1,4-benzoquinone in dioxane have been analyzed.Mono- and 2,3-bis-adducts were obtained and only in the case of pyrazole was a 2,5-bis(pyrazol-1-yl)-1,

Photoinduced intramolecular proton transfer as the mechanism of ultraviolet stabilizers: A reappraisal

Evidence based on theoretical calculations and photophysical experiments is presented to show that, contrary to general belief, the photostability of 2-(2′-hydroxy-5′-methylphenyl)benzotriazole (Tinuvin P) cannot be explained as being due to an excited-state intramolecular proton transfer (ESIPT) through the intramolecular hydrogen bond (IMHB). Support for this conclusion comes from a related study on several members of a new family of photostable compounds, namely the 1-(2′-hydroxyphenyl)pyrazoles, which were obtained by the reaction of pyrazole and of 3,5-dimethylpyrazole with benzoquinone. The structures of these pyrazole derivatives, namely 2,3-bis(3′,5′-dimethylpyrazol-1′-y1)-, 2,3-bis(pyrazol-1′-y1)-, 2-(pyrazol-1′-y1)-, and 2,5-bis(pyrazol-1′-y1)-1,4-dihydroxybenzene (1, 2, 3, and 4, respectively) were established by spectroscopic techniques and X-ray crystallography. Both derivatives 3 and 4 possess a strong intramolecular hydrogen bond and are reasonably photostable; derivatives 1 and 2 appear, however, to possess only a weak intramolecular hydrogen bond. 1 and 3 pack in helical systems, 4 does it with intercrossing stacking, and 2-H2O has a three-dimensional network involving water molecules.