123836-13-5

Basic information

• Product Name: 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3
• Synonyms: 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3
• CAS NO: 123836-13-5
• Molecular Formula: C₃₁H₄₈F₂O₄
• Molecular Weight: 0
• Mol File: 123836-13-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3(CAS DataBase Reference)
• NIST Chemistry Reference: 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3(123836-13-5)
• EPA Substance Registry System: 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3(123836-13-5)

Safety Data

• Hazardous Substances Data: 123836-13-5(Hazardous Substances Data)

Usage

General Description

24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3 is a synthetic analog of vitamin D3, which is a hormone that plays a key role in the regulation of calcium and phosphate metabolism in the body. This particular derivative of vitamin D3 has been modified to be more potent and longer-lasting, making it a promising candidate for the treatment of conditions such as osteoporosis and renal osteodystrophy. By targeting the vitamin D receptor, this compound can enhance the absorption of calcium and phosphate from the gut, as well as regulate their levels in the blood and bone. Additionally, it has been shown to have anti-inflammatory and immunomodulatory effects, making it a potential therapeutic option for conditions such as autoimmune diseases and cancer. Further research is needed to fully understand the potential benefits and risks of 24,24-difluoro-1,25-dihydroxy-26,27-dimethylvitamin D3 in clinical settings.

InChI:InChI=1/C29H46F2O3/c1-6-28(34,7-2)29(30,31)16-14-19(3)24-12-13-25-21(9-8-15-27(24,25)5)10-11-22-17-23(32)18-26(33)20(22)4/h10-11,19,23-26,32-34H,4,6-9,12-18H2,1-3,5H3/b21-10+,22-11-/t19-,23-,24-,25?,26?,27-/m1/s1

Upstream product

• 123836-12-4 24,24-difluoro-1α,25-dihydroxy-26,27-dimethyl-3,5-cyclovitamin D3 
• 64-19-7 acetic acid 
• 106647-61-4 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D₃ 
• 106647-58-9 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 3-acetate 
• 174293-44-8 ethyl 24,24-difluoro-23-hydroxy-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 123836-08-8 5α,8α-(3,5-dioxo-4-phenyl-1,2,4-triazolino)-24,24-difluoro-26,27-dimethylcholest-6-ene-3β,25-diol 3-acetate 
• 123836-01-1 ethyl 24,24-difluoro-23-<oxy>-3β-(methoxymethoxy)homochol-5-en-25-oate 
• 123836-10-2 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D₃ 3-tosylate 
• 106647-59-0 24,24-difluoro-26,27-dimethylcholesta-5,7-diene-3,25-diol 
• 123836-09-9 (R)-3-{(Z)-2-[(1R,3aR,7aR)-1-((R)-5-Ethyl-4,4-difluoro-5-hydroxy-1-methyl-heptyl)-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl]-vinyl}-4-methyl-cyclohex-3-enol 
• 123836-06-6 24,24-difluoro-26,27-dimethylcholest-5-ene-3β,25-diol 
• 123835-97-2 methyl 3β-(methoxymethoxy)-24-norchol-5-en-23-oate 
• 111478-66-1 3β-(methoxymethoxy)-24-norchol-5-en-23-al 
• 67711-02-8 3β-acetoxy-23,24-dinorchol-5-en-22-oyl chloride 

Downstream Products

• 106647-71-6 26,27-Dimethyl-24,24-difluoro-1,25-dihydroxyvitamin D₃ 

Relevant articles and documents

Synthesis and Biological Activity of Novel Vitamin D Analogues: 24,24-Difluoro-25-hydroxy-26,27-dimethylvitamin D3 and 24,24-Difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3

We synthesized 24,24-difluoro-25-hydroxy-26,27-dimethylvitamin D3 (16) and 24,24-difluoro-1α,25-dihydroxy-26,27-dimethylvitamin D3 (21), from 3β-hydroxy-22,23-dinorcholenic acid 3-acetate.Compound 16 was found to be a highly potent v