1238366-03-4

Basic information

• Product Name: C₁₈H₁₈N₂O₃
• Synonyms: C₁₈H₁₈N₂O₃
• CAS NO: 1238366-03-4
• Molecular Weight: 310.353
• Mol File: 1238366-03-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₁₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₁₈N₂O₃(1238366-03-4)
• EPA Substance Registry System: C₁₈H₁₈N₂O₃(1238366-03-4)

Safety Data

• Hazardous Substances Data: 1238366-03-4(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 134732-98-2 (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 

Downstream Products

• 1187932-04-2 (3S)-3-(aminomethyl)-3,4-dihydro-isoquinoline-2(1H)-carboxylic acid benzyl ester 

Relevant articles and documents

Synthesis of tetrahydroisoquinoline-diamine ligands and their application in asymmetric transfer hydrogenation

The use of the tetrahydroisoquinoline scaffold is well documented in biologically active compounds. However, reports of the utilisation of tetrahydroisoquinoline compounds in asymmetric catalysis are limited. The synthesis of novel diamine ligands possessing the tetrahydroisoquinoline (tetrahydroisoquinoline) backbone and evaluation of their activity in the asymmetric transfer hydrogenation of acetophenone are presented. The diamine ligands in conjunction with i-PrOH as the hydrogen source and [RhCl2(Cp*)]2 as the metal precursor proved to be the most effective of the tetrahydroisoquinoline derivatives for this catalytic system. Water was found to have a profound influence on the enantioselectivity of the reaction. Optimisation of the amount water, i-PrOH and catalytic loading content rendered the best result of 70% enantioselectivity for the (S)-1-phenylethanol isomer product.