123837-76-3

Upstream product

• 123837-60-5 2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester 
• 459-57-4 4-fluorobenzaldehyde 
• 123857-47-6 [2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-ylmethyl]-triphenyl-phosphonium; bromide 
• 123837-54-7 2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 2498-48-8 cyclohexanecarboximidamide hydrochloride 
• 123837-66-1 5-Bromomethyl-2-cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine 
• 123837-63-8 [2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol 
• 123837-72-9 5-{(E)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine 

Downstream Products

• 123837-79-6 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[2-cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-vinyl}-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)