123846-65-1

Usage

Uses

Used in Pharmaceutical Industry:
(3-Nitro-pyridin-2-yl)-acetonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (3-Nitro-pyridin-2-yl)-acetonitrile is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and yield.
Used in Organic Chemistry:
(3-Nitro-pyridin-2-yl)-acetonitrile is employed as a building block in organic chemical reactions, enabling the formation of more complex molecules for a wide range of applications, including the development of new materials and chemical compounds.
Safety and Storage:
Due to its potential hazards, (3-Nitro-pyridin-2-yl)-acetonitrile should be handled with care to avoid ingestion, inhalation, or skin contact, as it may be harmful. Additionally, it is crucial to store this chemical in a cool, dry, well-ventilated area, away from incompatible materials and sources of ignition to prevent any adverse reactions or environmental impact on aquatic organisms.

Upstream product

• 123846-70-8 Cyano-(3-nitro-pyridin-2-yl)-acetic acid tert-butyl ester 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 6332-56-5 3-nitropyridone 
• 142-08-5 2-Pyridone 
• 313366-96-0 ethyl (3-nitro-1,2-dihydro-2-pyridylidene)cyanoacetate 

Downstream Products

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 1018949-67-1 (3-aminopyridin-2-yl)acetonitrile 
• 1060718-02-6 (Z)-3-(4-methoxyphenyl)-2-(3-nitropyridin-2-yl)acrylonitrile 
• 25797-03-9 2-phenyl-1H-pyrrolo[3,2-b]pyridine 
• 153374-33-5 1-methyl-1H-pyrrolo[3,2-b]pyridine 

Relevant academic research and scientific papers

Synthesis and photochromic properties of 2-(3-nitro-2-pyridylmethyl)benzazoles

2-(3-Nitro-2-pyridylmethyl)benzazoles were synthesized, and their photochromic properties were studied by flash photolysis. Introduction of a nitropyridyl instead of the nitrophenyl moiety into the 2-methyl group insignificantly increases the basicity of the methylene group. Nitropyridyl-substituted benzazoles give rise to three detectable photoinduced forms: the corresponding union at pH > 10, azamerocyanine at pH ≈ 4, and monomethinecyanine at pH ≈ 1. Irradiation of solutions of weakly basic henzoxazole and benzothiazole derivatives at pH ≈ 4 results in formation of neutral chelate structures in which the hydrogen atom is linked simultaneously to two nitrogen atoms: one in the pyridine ring, and the second, in the azole ring.

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT6 receptor ligands, among which 6f and 6g showed high affinity for 5-HT6 receptors with Ki = 3.9 and 1.7 nM, respectively.

Synthesis of Some Nitropyridylacetonitriles

A new synthesis of nitropyridylacetonitriles 4 has been developed, using tert-butyl cyanoacetate and the corresponding chloropyridines 2.The tert-butyl esters are removed by acid-catalyzed dealkoxycarbonylation.