123846-69-5

Usage

Uses

Used in Pharmaceutical Industry:
(6-Chloro-3-nitro-pyridin-2-yl)-acetonitrile is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be a versatile building block in creating biologically active compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (6-Chloro-3-nitro-pyridin-2-yl)-acetonitrile serves as an intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
(6-Chloro-3-nitro-pyridin-2-yl)-acetonitrile is utilized as a precursor in organic synthesis reactions due to its reactive functional groups, which facilitate the formation of a wide range of chemical products for various applications across different industries.

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 65156-94-7 5-chloro-1H-pyrrolo[3,2-b]pyridine 

Relevant academic research and scientific papers

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties

A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clinical candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochemical properties and pharmacokinetic (PK) profiles of some prospective compounds.

Azaoxindole derivatives

This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.

Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines

Compounds of the formula STR1 wherein one of A, B, D and E is N and the remaining three atoms are C; R1 and R2 are independently selected from hydrogen and C1 to C6 alkyl; and R3, R4, R5 and R6 are independently selected from hydrogen, halogen, hydroxy, C1 -C6 alkyl, C1 -C8 alkoxy, phenyl-C1 -C6 alkoxy, phenoxy --NR7 R8 wherein R7 and R8 are independently selected from hydrogen, C1 -C8 alkyl, C1 -C6 alkanoyl and COOR9 wherein R9 is hydrogen or C1 -C6 alkyl, cyano, COOR10 wherein R10 is hydrogen or C1 -C6 alkyl, and CONR11 R12 where R10 and R11 are independently selected from hydrogen and C1 -C6 alkyl, and the pharmaceutically acceptable salts thereof. The compounds are useful psychotherapeutics and may be used in treating obesity, depression and disorders wherein aggression is a symptom.

Azaoxindole derivatives

This invention relates to novel 4-, 5-, 6-, and 7-azaoxindole derivatives. The compounds are anti-inflammatory and analgesic agents and inhibitors of one or more of prostaglandin H2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. They are useful in the treatment of chronic inflammatory diseases, allergy, psoriasis, various bone diseases, and immune dysfunctions such as systemic lupus erythematosis.

Synthesis of Some Nitropyridylacetonitriles

A new synthesis of nitropyridylacetonitriles 4 has been developed, using tert-butyl cyanoacetate and the corresponding chloropyridines 2.The tert-butyl esters are removed by acid-catalyzed dealkoxycarbonylation.