123858-51-5

Basic information

• Product Name: 1-(2-amino-4-bromophenyl)ethanone
• Synonyms: 1-(2-amino-4-bromophenyl)ethanone;1-(2-AMino-6-broMophenyl)ethanone;1-(2-Amino-4-bromophenyl);Ethanone, 1-(2-amino-4-bromophenyl)-
• CAS NO: 123858-51-5
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.05922
• Mol File: 123858-51-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 82-84℃
• Boiling Point: 322.926°C at 760 mmHg
• Flash Point: 149.101°C
• Appearance: /
• Density: 1.535
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.23±0.10(Predicted)
• CAS DataBase Reference: 1-(2-amino-4-bromophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-amino-4-bromophenyl)ethanone(123858-51-5)
• EPA Substance Registry System: 1-(2-amino-4-bromophenyl)ethanone(123858-51-5)

Safety Data

• Hazardous Substances Data: 123858-51-5(Hazardous Substances Data)

Usage

General Description

1-(2-amino-4-bromophenyl)ethanone, also known as 4-bromo-2-aminophenyl ethanone, is a chemical compound with the molecular formula C8H8BrNO. This organic compound consists of a benzene ring with a bromine atom and an amino group attached to it. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. The presence of the bromine and amino groups makes it a versatile building block for the production of various compounds. Additionally, it is used in research and development as a reagent for various chemical reactions and processes. 1-(2-amino-4-bromophenyl)ethanone has potential applications in the pharmaceutical, agricultural, and industrial sectors, making it an important and valuable chemical.

InChI:InChI=1/C8H8BrNO/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,10H2,1H3

Upstream product

• 304858-65-9 2-amino-4-bromobenzonitrile 
• 75-16-1 methylmagnesium bromide 
• 591-19-5 m-Bromoaniline 
• 107-12-0 propiononitrile 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 1438400-32-8 N-(2-acetyl-5-bromophenyl)-4-methylbenzenesulfonamide 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 917-54-4 methyllithium 
• 75-05-8 acetonitrile 
• 90004-94-7 4’-bromo-2’-nitroacetophenone 

Downstream Products

• 1357259-66-5 C₂₅H₂₅BrN₂O₃ 
• 1357259-65-4 C₂₅H₂₇BrN₂O₄ 
• 1357259-69-8 C₂₀H₂₅BrN₂O₄ 
• 1800426-14-5 7-bromo-4-chlorocinnoline 

Relevant articles and documents

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Pd-catalyzed regiodivergent synthesis of diverse oxindoles enabled by the versatile heck reaction of carbamoyl chlorides

We report herein a miscellaneous oxindole synthesis bearing an all-carbon quaternary center, enabled by Pd-catalyzed intramolecular cyclization followed by multiple intermolecular Heck reactions of both easily accessible alkene-tethered carbamoyl chlorides and olefins. This protocol obviates the use of prefunctionalized olefinic reagents, exhibits excellent functional group tolerance, and features fascinating reactive versatility.

A process for the preparation method of the compound aromatic amines (by machine translation)

The invention discloses a method for preparing aromatic amine compounds, comprising the following steps: under protection of inert gas, with the ratio of the phenolic compound amine according to mole 1:2 - 40 are mixed and dissolved in the solvent, 50 - 140 °C reaction 6 - 15 hours, corresponding to preparing polymerizable aromatic amine compound, and then after treatment to obtain a pure aromatic amine compound. Raw materials of this invention generally are easy, simple operation, substrate and wide range of application, in the absence of catalyst under catalytic conditions of the phenolic compound can be obtained by nucleophilic addition reaction of the corresponding aromatic amine compound, and is suitable for industrial production. The present invention allows the presence of water in the reaction system, can be ammonia or hydrazine hydrate as the substrate, in order to ammonium chloride as a catalyst and a cosolvent, the success of the preparation to obtain a level from phenol hydroxy aromatic primary amino compound. The invention to phenol hydroxy has better selectivity, even if the presence of halogen atoms in the substrate does not affect the occurrence of the reaction. (by machine translation)