1238603-69-4Relevant articles and documents
Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Lv, Binhua,Feng, Yan,Dong, Jiajia,Xu, Min,Xu, Baihua,Zhang, Wenbin,Sheng, Zelin,Welihinda, Ajith,Seed, Brian,Chen, Yuanwei
, p. 827 - 831 (2010)
(Chemical Equation Presented) Sodium glucose co-transporter 2 (SGLT2) is an emerging target for the treatment of type 2 diabetes mellitus (DM2). Here, the synthesis and preliminary biological evaluation of a series of potent, selective SGLT2 inhibitors, derived from a rigid spiro C-arylglucoside scaffold, is described.
