1238679-32-7Relevant academic research and scientific papers
Acid-catalysed or radical-promoted allylic substitution of 2-methylene-2, 3dihydrobenzofuran-3-ols with thiol derivatives: A novel and expedient synthesis of 2-(thiomethyl)benzofurans
Gabriele, Bartolo,Mancuso, Raffaella,Salerno, Giuseppe
, p. 3459 - 3464 (2010)
The 2-thiomethylbenzofuran derivatives 3 are conveniently prepared in good yields through the reactions between the readily available 2-methylene-2, 3-dihydrobenzofuran-3-ols 1 and the thiol derivatives 2 (including alkyl thiols, thiophenol, and thioacetic acid). The allylic substitution process may be either acid-catalysed or promoted by radical initiators. In the first case, the reactions are carried out at 90 °C in 1, 2-dimethoxyethane (DME) as the solvent in the presence of H2SO4 as the proton source. The radical-promoted reactions take place in DME at: 90 °C in the presence of azobis(isobutyronitrile) (AIBN) or benzoyl peroxide (BP) as the radical initiator.
