1238824-71-9

Basic information

• Product Name: C₆₂H₉₀N₁₂O₉S₆
• CAS NO: 1238824-71-9
• Molecular Weight: 1339.87
• Mol File: 1238824-71-9.mol

Chemical Properties

• CAS DataBase Reference: C₆₂H₉₀N₁₂O₉S₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₆₂H₉₀N₁₂O₉S₆(1238824-71-9)
• EPA Substance Registry System: C₆₂H₉₀N₁₂O₉S₆(1238824-71-9)

Safety Data

• Hazardous Substances Data: 1238824-71-9(Hazardous Substances Data)

Upstream product

• 1238824-62-8 (4-((1-((3S,5S)-5-(bis(ethylthio)methyl)-1-(4-(5-(4-((4-((S)-2-(bis(ethylthio)methyl)pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenoxy)methyl)-1H-1,2,3-triazol-1-yl)pentyloxy)-5-methoxy-2-nitrobenzoyl)pyrrolidin-3-yl)-1H-1,2,3-triazol-4-yl)methoxy)-5-methoxy-2-nitrophenyl)((S)-2-(bis(ethylthio)methyl)pyrrolidin-1-yl)methanone 

Relevant articles and documents

Synthesis of bis-1,2,3-triazolo-bridged unsymmetrical pyrrolobenzodiazepine trimers via 'click' chemistry and their DNA-binding studies

New conceivable synthetic approach for the construction of nitrogen-rich 1,2,3-triazolo-pyrrolo[2,1-c] [1,4]benzodiazepine (TPBD, 3ac) trimers has been developed.The first example of a bis-1,2,3-triazolo-bridged unsymmetrical PBD trimer has been successfully synthesized by employing a CuAAC type 'click' chemistry protocol.This efficient route generates tri-imine functionality in a single molecule.It has been envisaged that such tri-imine functionalities could bring in efficient interaction with DNA in a sequence-selective manner in the minor groove of duplex DNA.One of the representative analogues 3c has shown improved DNA-binding ability (DTm 23.7 °C) by thermal denaturation studies using CT-DNA and this data is also supported by molecular modeling (MD) studies.