123885-92-7Relevant academic research and scientific papers
Bisbenzamidine derivatives for use as antioxidant
-
, (2009/12/05)
The invention is directed to the use of bisbenzamidine compounds of Formula (I) as antioxidant and as neuroprotective agents, wherein R1, R2, R3, R4 and L have the meaning defined in the claims.
Antitumor and anti-Pneumocystis carinii activities of novel bisbenzamidines
Vanden Eynde, Jean Jacques,Mayence, Annie,Johnson, Melissa T.,Huang, Tien L.,Collins, Margaret S.,Rebholz, Sandra,Walzer, Peter D.,Cushion, Melanie T.,Donkor, Isaac O.
, p. 143 - 157 (2007/10/03)
Among a library of 17 bisbenzamidines connected with various linkers, compounds with a flexible pentanediamide (10) or hexanediamide (12) linker were the most potent derivatives against rat Pneumocystis carinii (IC50 values of 3 and 2 nM, respe
Trypanocidal activity of conformationally restricted pentamidine congeners
Donkor, Isaac O.,Huang, Tien L.,Tao, Bin,Rattendi, Donna,Lane, Schennella,Vargas, Marc,Goldberg, Burt,Bacchi, Cyrus
, p. 1041 - 1048 (2007/10/03)
A series of conformationally restricted congeners of pentamidine in which the flexible pentyl bridge of pentamidine was replaced by trans-1,2-bismethylenecyclopropyl, phenyl, pyridinyl, piperazinyl, homopiperazinyl, and piperidinyl groups were synthesized
