1238951-65-9Relevant academic research and scientific papers
ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS
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Page/Page column 9; 10, (2012/12/13)
Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.
1-Substituted 4-(3-Hydroxyphenyl)piperazines are pure opioid receptor antagonists
Carroll, F. Ivy,Cueva, Juan Pablo,Thomas, James B.,Mascarella, S. Wayne,Runyon, Scott P.,Navarro, Hernan A.
scheme or table, p. 365 - 369 (2010/11/18)
This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl) piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxyphenyl)piperazine, both of which display low nanomolar potencies at μ, δ, and κ receptors and pure antagonist properties in a [35S]GTPγS assay.
