1239028-00-2

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 89-57-6 5-Aminosalicylic Acid 

Downstream Products

• 1239028-15-9 N-(3-trifluoromethylphenyl)-2-hydroxy-5-[4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl]benzamide 
• 1239028-13-7 2-hydroxy-5-[4-(3-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]-N-(3-trifluoromethylphenyl)benzamide 
• 1239028-04-6 N-(3-trifluoromethylphenyl)-2-hydroxy-5-[4-(2,5-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]benzamide 
• 1239028-14-8 N-(3-trifluoromethylphenyl)-2-hydroxy-5-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]benzamide 

Relevant academic research and scientific papers

Click approach to the discovery of 1,2,3-triazolylsalicylamides as potent Aurora kinase inhibitors

A series of 1,2,3-triazolylsalicylamide derivatives has been developed from the antiproliferative agent 7 and was evaluated for their Aurora kinase inhibitory activity. The novel 1,2,3-triazolylsalicylamide scaffold could be readily assembled by Cu(I)-cat

Novel triazolylsalicylamide derivatives with aurora kinase inhibiting activity

The present invention relates to a novel triazolyl salicylamide derivative having aurora kinase inhibiting activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient. The novel tria

A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly

Lavendustin-mimetic small molecules modifying the linker -CH 2-NH- with an 1,2,3-triazole ring have been synthesized via a click chemistry. Two pharmacophoric fragments of lavendustin were varied to investigate chemical space and the auxophoric -CH2-NH- was altered to an 1,2,3-triazole for rapid click conjugation. The small molecules were evaluated against HCT116 colon cancer and CCRF-CEM leukemia cell lines. Among 28 analogues, 3-phenylpropyl ester 26b inhibited CCRF-CEM leukemia cell growth with GI50 value of 0.9 μM.