1239028-01-3

Upstream product

• 122-97-4 3-Phenyl-1-propanol 

Downstream Products

• 1239028-17-1 3-phenylpropyl 2-hydroxy-5-[4-(2,5-dihydroxyphenyl)-1H-1,2,3-triazol-1-yl]benzoate 
• 1239028-18-2 3-phenylpropyl 2-hydroxy-5-[4-(3-hydroxyphenyl)-1H-1,2,3-triazol-1-yl]benzoate 
• 1239028-05-7 3-phenylpropyl 2-hydroxy-5-[4-(2,5-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]benzoate 
• 1239028-19-3 3-phenylpropyl 2-hydroxy-5-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]benzoate 

Relevant academic research and scientific papers

A rapid synthesis of lavendustin-mimetic small molecules by click fragment assembly

Lavendustin-mimetic small molecules modifying the linker -CH 2-NH- with an 1,2,3-triazole ring have been synthesized via a click chemistry. Two pharmacophoric fragments of lavendustin were varied to investigate chemical space and the auxophoric -CH2-NH- was altered to an 1,2,3-triazole for rapid click conjugation. The small molecules were evaluated against HCT116 colon cancer and CCRF-CEM leukemia cell lines. Among 28 analogues, 3-phenylpropyl ester 26b inhibited CCRF-CEM leukemia cell growth with GI50 value of 0.9 μM.