123910-63-4

Upstream product

• 103-82-2 phenylacetic acid 
• 6456-74-2 Glycine tert-butyl ester 
• 27532-96-3 glycine tert-butyl ester hydrochloride 
• 543-27-1 isobutyl chloroformate 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 500-98-1 phenylacetylglycine 

Relevant academic research and scientific papers

Regioselective synthesis of: Ortho -iodobiphenylboronic acid derivatives: A superior catalyst for carboxylic acid activation

An efficient and versatile synthesis of ortho-iodobiphenylboronic acids via the highly regioselective metal-iodine exchange (MIE) of 2,3-diiodobiphenyls is reported. The site-selectivity is very much controlled by the size of the biphenyl fragment, providing only the terminal arylboronic acid derivatives in excellent site-selectivity. The nature of the substituents (R1 and R2) on the biphenyls is found to have an influence on the reactivity but not on the regioselectivity. The best reactivity and the highest isolated yields were furnished with products bearing electron-donating groups. The synthesized derivatives were also tested for in vitro antimicrobial activity against four strains of bacteria and one fungal strain. This revealed that (2-iodo-4′-isopropyl-[1,1′-biphenyl]-3-yl)boronic acid 6A and (3-(benzo[d][1,3]dioxol-5-yl)-2-iodo-5-methoxyphenyl)boronic acid 22A possess the most potent antibacterial and antifungal activity with MICs of 0.10 and 0.3 mg mL-1 for B. cereus and C. albicans respectively. The catalytic activity was also examined towards an amidation reaction at ambient temperature and this revealed a new optimal catalyst, (2-iodo-4′,5-dimethoxy-[1,1′-biphenyl]-3-yl)boronic acid 19A providing a remarkable increase in the amide yields, including α-aminoacids. This work discloses a protocol for the first synthesis of hitherto unknown ortho-iodobiphenylboronic acid derivatives that is scalable, and general in scope, where no chromatographic purification is necessary and the products are indeed potential organocatalysts.

The use of cellulose (chromatography paper) as a cheap, versatile and non-covalent support for organic molecules during multi-step synthesis

Cellulose chromatography paper provides a novel non-covalent support for synthesis and in-situ purification of multi-dimensional arrays.

Derivatives of L-proline, their preparation and their biological uses

The L-proline derivatives of the invention correspond to the Formula I: STR1 in which R1 corresponds to the Formula II: STR2 in which R is a carbonyl group, an acyl group --Y--CO-- or an oxy-acyl group --O--Y--CO--, Y being an alkyl or an alkenyl chain, Z being one or more hydrogen atoms, or one or more substituents chosen from among halogen atoms, CF3, alkyl or alkoxy groups and an alkylenedioxy group in the case of two neighbouring substituents, R2 is --NH2, --OH, or a derivative of these groups, A1 and A2 are amino acid residues and B1 and B2 represents a hydrogen atom or a methyl group, and the pharmacologically acceptable salts of these derivatives. These derivatives are useful particularly as the active principles of medicines possessing, in particular, a nootropic action.