1239130-22-3

Basic information

• Product Name: 3-methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine
• Synonyms: 3-methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine;1H-Pyrazol-3-amine, 5-methyl-4-(3-methylphenyl)-
• CAS NO: 1239130-22-3
• Molecular Formula: C11H13N3
• Molecular Weight: 187.24
• Mol File: 1239130-22-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 369.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.162±0.06 g/cm3(Predicted)
• PKA: 15.78±0.50(Predicted)
• CAS DataBase Reference: 3-methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine(1239130-22-3)
• EPA Substance Registry System: 3-methyl-4-(3-methylphenyl)-1H-pyrazol-5-amine(1239130-22-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1239130-22-3(Hazardous Substances Data)

Upstream product

• 2947-60-6 3-methylbenzyl cyanide 
• 38377-59-2 2-(3-methylphenyl)-3-oxobutanenitrile 

Relevant articles and documents

N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

NF-κB-inducing kinase (NIK), an oncogenic drug target that is associated with various cancers, is a central signalling component of the non-canonical pathway. A blind screening process, which established that amino pyrazole related scaffolds have an effect on IKKbeta, led to a hit-to-lead optimization process that identified the aminopyrazole 3a as a low μM selective NIK inhibitor. Compound 3a effectively inhibited the NIK-dependent activation of the NF-κB pathway in tumour cells, confirming its selective inhibitory profile.